Despite the increasing use of deep learning in medical image segmentation, acquiring sufficient training data remains a challenge in the medical field. In response, data augmentation techniques have been proposed; however, the generation of diverse and realistic medical images and their corresponding masks remains a difficult task, especially when working with insufficient training sets. To address these limitations, we present an end-to-end architecture based on the Hamiltonian Variational Autoencoder (HVAE). This approach yields an improved posterior distribution approximation compared to traditional Variational Autoencoders (VAE), resulting in higher image generation quality. Our method outperforms generative adversarial architectures under data-scarce conditions, showcasing enhancements in image quality and precise tumor mask synthesis. We conduct experiments on two publicly available datasets, MICCAI's Brain Tumor Segmentation Challenge (BRATS), and Head and Neck Tumor Segmentation Challenge (HECKTOR), demonstrating the effectiveness of our method on different medical imaging modalities.
Deep learning has become a popular tool for medical image analysis, but the limited availability of training data remains a major challenge, particularly in the medical field where data acquisition can be costly and subject to privacy regulations. Data augmentation techniques offer a solution by artificially increasing the number of training samples, but these techniques often produce limited and unconvincing results. To address this issue, a growing number of studies have proposed the use of deep generative models to generate more realistic and diverse data that conform to the true distribution of the data. In this review, we focus on three types of deep generative models for medical image augmentation: variational autoencoders, generative adversarial networks, and diffusion models. We provide an overview of the current state of the art in each of these models and discuss their potential for use in different downstream tasks in medical imaging, including classification, segmentation, and cross-modal translation. We also evaluate the strengths and limitations of each model and suggest directions for future research in this field. Our goal is to provide a comprehensive review about the use of deep generative models for medical image augmentation and to highlight the potential of these models for improving the performance of deep learning algorithms in medical image analysis.