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An LLM-Based Digital Twin for Optimizing Human-in-the Loop Systems
Mar 25, 2024
The increasing prevalence of Cyber-Physical Systems and the Internet of Things (CPS-IoT) applications and Foundation Models are enabling new applications that leverage real-time control of the environment. For example, real-time control of Heating, Ventilation and Air-Conditioning (HVAC) systems can reduce its usage when not needed for the comfort of human occupants, hence reducing energy consumption. Collecting real-time feedback on human preferences in such human-in-the-loop (HITL) systems, however, is difficult in practice. We propose the use of large language models (LLMs) to deal with the challenges of dynamic environments and difficult-to-obtain data in CPS optimization. In this paper, we present a case study that employs LLM agents to mimic the behaviors and thermal preferences of various population groups (e.g. young families, the elderly) in a shopping mall. The aggregated thermal preferences are integrated into an agent-in-the-loop based reinforcement learning algorithm AitL-RL, which employs the LLM as a dynamic simulation of the physical environment to learn how to balance between energy savings and occupant comfort. Our results show that LLMs are capable of simulating complex population movements within large open spaces. Besides, AitL-RL demonstrates superior performance compared to the popular existing policy of set point control, suggesting that adaptive and personalized decision-making is critical for efficient optimization in CPS-IoT applications. Through this case study, we demonstrate the potential of integrating advanced Foundation Models like LLMs into CPS-IoT to enhance system adaptability and efficiency. The project's code can be found on our GitHub repository.
Assisting Clinical Decisions for Scarcely Available Treatment via Disentangled Latent Representation
Jul 06, 2023
Extracorporeal membrane oxygenation (ECMO) is an essential life-supporting modality for COVID-19 patients who are refractory to conventional therapies. However, the proper treatment decision has been the subject of significant debate and it remains controversial about who benefits from this scarcely available and technically complex treatment option. To support clinical decisions, it is a critical need to predict the treatment need and the potential treatment and no-treatment responses. Targeting this clinical challenge, we propose Treatment Variational AutoEncoder (TVAE), a novel approach for individualized treatment analysis. TVAE is specifically designed to address the modeling challenges like ECMO with strong treatment selection bias and scarce treatment cases. TVAE conceptualizes the treatment decision as a multi-scale problem. We model a patient's potential treatment assignment and the factual and counterfactual outcomes as part of their intrinsic characteristics that can be represented by a deep latent variable model. The factual and counterfactual prediction errors are alleviated via a reconstruction regularization scheme together with semi-supervision, and the selection bias and the scarcity of treatment cases are mitigated by the disentangled and distribution-matched latent space and the label-balancing generative strategy. We evaluate TVAE on two real-world COVID-19 datasets: an international dataset collected from 1651 hospitals across 63 countries, and a institutional dataset collected from 15 hospitals. The results show that TVAE outperforms state-of-the-art treatment effect models in predicting both the propensity scores and factual outcomes on heterogeneous COVID-19 datasets. Additional experiments also show TVAE outperforms the best existing models in individual treatment effect estimation on the synthesized IHDP benchmark dataset.