Marie-Karelle Riviere

On Multi-Armed Bandit Designs for Phase I Clinical Trials

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We study the problem of finding the optimal dosage in a phase I clinical trial through the multi-armed bandit lens. We advocate the use of the Thompson Sampling principle, a flexible algorithm that can accommodate different types of monotonicity assumptions on the toxicity and efficacy of the doses. For the simplest version of Thompson Sampling, based on a uniform prior distribution for each dose, we provide finite-time upper bounds on the number of sub-optimal dose selections, which is unprecedented for dose finding algorithms. Through a large simulation study, we then show that Thompson Sampling based on more sophisticated prior distributions outperform state-of-the-art dose identification algorithms in different types of phase I clinical trials.

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