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Benchmarking the Cell Image Segmentation Models Robustness under the Microscope Optical Aberrations
Apr 12, 2024
Cell segmentation is essential in biomedical research for analyzing cellular morphology and behavior. Deep learning methods, particularly convolutional neural networks (CNNs), have revolutionized cell segmentation by extracting intricate features from images. However, the robustness of these methods under microscope optical aberrations remains a critical challenge. This study comprehensively evaluates the performance of cell instance segmentation models under simulated aberration conditions using the DynamicNuclearNet (DNN) and LIVECell datasets. Aberrations, including Astigmatism, Coma, Spherical, and Trefoil, were simulated using Zernike polynomial equations. Various segmentation models, such as Mask R-CNN with different network heads (FPN, C3) and backbones (ResNet, VGG19, SwinS), were trained and tested under aberrated conditions. Results indicate that FPN combined with SwinS demonstrates superior robustness in handling simple cell images affected by minor aberrations. Conversely, Cellpose2.0 proves effective for complex cell images under similar conditions. Our findings provide insights into selecting appropriate segmentation models based on cell morphology and aberration severity, enhancing the reliability of cell segmentation in biomedical applications. Further research is warranted to validate these methods with diverse aberration types and emerging segmentation models. Overall, this research aims to guide researchers in effectively utilizing cell segmentation models in the presence of minor optical aberrations.
Pneumonia App: a mobile application for efficient pediatric pneumonia diagnosis using explainable convolutional neural networks (CNN)
Mar 31, 2024Mycoplasma pneumoniae pneumonia (MPP) poses significant diagnostic challenges in pediatric healthcare, especially in regions like China where it's prevalent. We introduce PneumoniaAPP, a mobile application leveraging deep learning techniques for rapid MPP detection. Our approach capitalizes on convolutional neural networks (CNNs) trained on a comprehensive dataset comprising 3345 chest X-ray (CXR) images, which includes 833 CXR images revealing MPP and additionally augmented with samples from a public dataset. The CNN model achieved an accuracy of 88.20% and an AUROC of 0.9218 across all classes, with a specific accuracy of 97.64% for the mycoplasma class, as demonstrated on the testing dataset. Furthermore, we integrated explainability techniques into PneumoniaAPP to aid respiratory physicians in lung opacity localization. Our contribution extends beyond existing research by targeting pediatric MPP, emphasizing the age group of 0-12 years, and prioritizing deployment on mobile devices. This work signifies a significant advancement in pediatric pneumonia diagnosis, offering a reliable and accessible tool to alleviate diagnostic burdens in healthcare settings.
A self-organizing multi-agent system for distributed voltage regulation
Feb 01, 2022
This paper presents a distributed voltage regulation method based on multi-agent system control and network self-organization for a large distribution network. The network autonomously organizes itself into small subnetworks through the epsilon decomposition of the sensitivity matrix, and agents group themselves into these subnetworks with the communication links being autonomously determined. Each subnetwork controls its voltage by locating the closest local distributed generation and optimizing their outputs. This simplifies and reduces the size of the optimization problem and the interaction requirements. This approach also facilitates adaptive grouping of the network by self-reorganizing to maintain a stable state in response to time-varying network requirements and changes. The effectiveness of the proposed approach is validated through simulations on a model of a real heavily-meshed secondary distribution network. Simulation results and comparisons with other methods demonstrate the ability of the subnetworks to autonomously and independently regulate the voltage and to adapt to unpredictable network conditions over time, thereby enabling autonomous and flexible distribution networks.