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Add to EdgeGeneration of Synthetic Rat Brain MRI scans with a 3D Enhanced Alpha-GAN
Jan 04, 2022
Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the availability of MRI scanners and the time required for a full scanning session (it usually takes over 30 minutes). Privacy laws and the 3Rs ethics rule also make it difficult to create large datasets for training deep learning models. Generative Adversarial Networks (GANs) can perform data augmentation with higher quality than other techniques. In this work, the alpha-GAN architecture is used to test its ability to produce realistic 3D MRI scans of the rat brain. As far as the authors are aware, this is the first time that a GAN-based approach has been used for data augmentation in preclinical data. The generated scans are evaluated using various qualitative and quantitative metrics. A Turing test conducted by 4 experts has shown that the generated scans can trick almost any expert. The generated scans were also used to evaluate their impact on the performance of an existing deep learning model developed for segmenting the rat brain into white matter, grey matter and cerebrospinal fluid. The models were compared using the Dice score. The best results for whole brain and white matter segmentation were obtained when 174 real scans and 348 synthetic scans were used, with improvements of 0.0172 and 0.0129, respectively. Using 174 real scans and 87 synthetic scans resulted in improvements of 0.0038 and 0.0764 for grey matter and CSF segmentation, respectively. Thus, by using the proposed new normalisation layer and loss functions, it was possible to improve the realism of the generated rat MRI scans and it was shown that using the generated data improved the segmentation model more than using the conventional data augmentation.
Spatio-temporal wavelet regularization for parallel MRI reconstruction: application to functional MRI
Oct 03, 2013
Parallel MRI is a fast imaging technique that enables the acquisition of highly resolved images in space or/and in time. The performance of parallel imaging strongly depends on the reconstruction algorithm, which can proceed either in the original k-space (GRAPPA, SMASH) or in the image domain (SENSE-like methods). To improve the performance of the widely used SENSE algorithm, 2D- or slice-specific regularization in the wavelet domain has been deeply investigated. In this paper, we extend this approach using 3D-wavelet representations in order to handle all slices together and address reconstruction artifacts which propagate across adjacent slices. The gain induced by such extension (3D-Unconstrained Wavelet Regularized -SENSE: 3D-UWR-SENSE) is validated on anatomical image reconstruction where no temporal acquisition is considered. Another important extension accounts for temporal correlations that exist between successive scans in functional MRI (fMRI). In addition to the case of 2D+t acquisition schemes addressed by some other methods like kt-FOCUSS, our approach allows us to deal with 3D+t acquisition schemes which are widely used in neuroimaging. The resulting 3D-UWR-SENSE and 4D-UWR-SENSE reconstruction schemes are fully unsupervised in the sense that all regularization parameters are estimated in the maximum likelihood sense on a reference scan. The gain induced by such extensions is illustrated on both anatomical and functional image reconstruction, and also measured in terms of statistical sensitivity for the 4D-UWR-SENSE approach during a fast event-related fMRI protocol. Our 4D-UWR-SENSE algorithm outperforms the SENSE reconstruction at the subject and group levels (15 subjects) for different contrasts of interest (eg, motor or computation tasks) and using different parallel acceleration factors (R=2 and R=4) on 2x2x3mm3 EPI images.
4D Wavelet-Based Regularization for Parallel MRI Reconstruction: Impact on Subject and Group-Levels Statistical Sensitivity in fMRI
Mar 17, 2011
Parallel MRI is a fast imaging technique that enables the acquisition of highly resolved images in space. It relies on $k$-space undersampling and multiple receiver coils with complementary sensitivity profiles in order to reconstruct a full Field-Of-View (FOV) image. The performance of parallel imaging mainly depends on the reconstruction algorithm, which can proceed either in the original $k$-space (GRAPPA, SMASH) or in the image domain (SENSE-like methods). To improve the performance of the widely used SENSE algorithm, 2D- or slice-specific regularization in the wavelet domain has been efficiently investigated. In this paper, we extend this approach using 3D-wavelet representations in order to handle all slices together and address reconstruction artifacts which propagate across adjacent slices. The extension also accounts for temporal correlations that exist between successive scans in functional MRI (fMRI). The proposed 4D reconstruction scheme is fully \emph{unsupervised} in the sense that all regularization parameters are estimated in the maximum likelihood sense on a reference scan. The gain induced by such extensions is first illustrated on EPI image reconstruction but also measured in terms of statistical sensitivity during a fast event-related fMRI protocol. The proposed 4D-UWR-SENSE algorithm outperforms the SENSE reconstruction at the subject and group-levels (15 subjects) for different contrasts of interest and using different parallel acceleration factors on $2\times2\times3$mm$^3$ EPI images.