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Learning to Describe for Predicting Zero-shot Drug-Drug Interactions
Mar 13, 2024
Adverse drug-drug interactions~(DDIs) can compromise the effectiveness of concurrent drug administration, posing a significant challenge in healthcare. As the development of new drugs continues, the potential for unknown adverse effects resulting from DDIs becomes a growing concern. Traditional computational methods for DDI prediction may fail to capture interactions for new drugs due to the lack of knowledge. In this paper, we introduce a new problem setup as zero-shot DDI prediction that deals with the case of new drugs. Leveraging textual information from online databases like DrugBank and PubChem, we propose an innovative approach TextDDI with a language model-based DDI predictor and a reinforcement learning~(RL)-based information selector, enabling the selection of concise and pertinent text for accurate DDI prediction on new drugs. Empirical results show the benefits of the proposed approach on several settings including zero-shot and few-shot DDI prediction, and the selected texts are semantically relevant. Our code and data are available at \url{https://github.com/zhufq00/DDIs-Prediction}.
A Diffusion Model for Event Skeleton Generation
May 27, 2023
Event skeleton generation, aiming to induce an event schema skeleton graph with abstracted event nodes and their temporal relations from a set of event instance graphs, is a critical step in the temporal complex event schema induction task. Existing methods effectively address this task from a graph generation perspective but suffer from noise-sensitive and error accumulation, e.g., the inability to correct errors while generating schema. We, therefore, propose a novel Diffusion Event Graph Model~(DEGM) to address these issues. Our DEGM is the first workable diffusion model for event skeleton generation, where the embedding and rounding techniques with a custom edge-based loss are introduced to transform a discrete event graph into learnable latent representation. Furthermore, we propose a denoising training process to maintain the model's robustness. Consequently, DEGM derives the final schema, where error correction is guaranteed by iteratively refining the latent representation during the schema generation process. Experimental results on three IED bombing datasets demonstrate that our DEGM achieves better results than other state-of-the-art baselines. Our code and data are available at https://github.com/zhufq00/EventSkeletonGeneration.
A Generative Approach for Script Event Prediction via Contrastive Fine-tuning
Dec 09, 2022
Script event prediction aims to predict the subsequent event given the context. This requires the capability to infer the correlations between events. Recent works have attempted to improve event correlation reasoning by using pretrained language models and incorporating external knowledge~(e.g., discourse relations). Though promising results have been achieved, some challenges still remain. First, the pretrained language models adopted by current works ignore event-level knowledge, resulting in an inability to capture the correlations between events well. Second, modeling correlations between events with discourse relations is limited because it can only capture explicit correlations between events with discourse markers, and cannot capture many implicit correlations. To this end, we propose a novel generative approach for this task, in which a pretrained language model is fine-tuned with an event-centric pretraining objective and predicts the next event within a generative paradigm. Specifically, we first introduce a novel event-level blank infilling strategy as the learning objective to inject event-level knowledge into the pretrained language model, and then design a likelihood-based contrastive loss for fine-tuning the generative model. Instead of using an additional prediction layer, we perform prediction by using sequence likelihoods generated by the generative model. Our approach models correlations between events in a soft way without any external knowledge. The likelihood-based prediction eliminates the need to use additional networks to make predictions and is somewhat interpretable since it scores each word in the event. Experimental results on the multi-choice narrative cloze~(MCNC) task demonstrate that our approach achieves better results than other state-of-the-art baselines. Our code will be available at https://github.com/zhufq00/mcnc.