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A Novel Approach for Stable Selection of Informative Redundant Features from High Dimensional fMRI Data
May 25, 2016
Feature selection is among the most important components because it not only helps enhance the classification accuracy, but also or even more important provides potential biomarker discovery. However, traditional multivariate methods is likely to obtain unstable and unreliable results in case of an extremely high dimensional feature space and very limited training samples, where the features are often correlated or redundant. In order to improve the stability, generalization and interpretations of the discovered potential biomarker and enhance the robustness of the resultant classifier, the redundant but informative features need to be also selected. Therefore we introduced a novel feature selection method which combines a recent implementation of the stability selection approach and the elastic net approach. The advantage in terms of better control of false discoveries and missed discoveries of our approach, and the resulted better interpretability of the obtained potential biomarker is verified in both synthetic and real fMRI experiments. In addition, we are among the first to demonstrate the robustness of feature selection benefiting from the incorporation of stability selection and also among the first to demonstrate the possible unrobustness of the classical univariate two-sample t-test method. Specifically, we show the robustness of our feature selection results in existence of noisy (wrong) training labels, as well as the robustness of the resulted classifier based on our feature selection results in the existence of data variation, demonstrated by a multi-center attention-deficit/hyperactivity disorder (ADHD) fMRI data.
Randomized Structural Sparsity based Support Identification with Applications to Locating Activated or Discriminative Brain Areas: A Multi-center Reproducibility Study
Jun 07, 2015
In this paper, we focus on how to locate the relevant or discriminative brain regions related with external stimulus or certain mental decease, which is also called support identification, based on the neuroimaging data. The main difficulty lies in the extremely high dimensional voxel space and relatively few training samples, easily resulting in an unstable brain region discovery (or called feature selection in context of pattern recognition). When the training samples are from different centers and have betweencenter variations, it will be even harder to obtain a reliable and consistent result. Corresponding, we revisit our recently proposed algorithm based on stability selection and structural sparsity. It is applied to the multi-center MRI data analysis for the first time. A consistent and stable result is achieved across different centers despite the between-center data variation while many other state-of-the-art methods such as two sample t-test fail. Moreover, we have empirically showed that the performance of this algorithm is robust and insensitive to several of its key parameters. In addition, the support identification results on both functional MRI and structural MRI are interpretable and can be the potential biomarkers.
Randomized Structural Sparsity via Constrained Block Subsampling for Improved Sensitivity of Discriminative Voxel Identification
Jun 07, 2015
In this paper, we consider voxel selection for functional Magnetic Resonance Imaging (fMRI) brain data with the aim of finding a more complete set of probably correlated discriminative voxels, thus improving interpretation of the discovered potential biomarkers. The main difficulty in doing this is an extremely high dimensional voxel space and few training samples, resulting in unreliable feature selection. In order to deal with the difficulty, stability selection has received a great deal of attention lately, especially due to its finite sample control of false discoveries and transparent principle for choosing a proper amount of regularization. However, it fails to make explicit use of the correlation property or structural information of these discriminative features and leads to large false negative rates. In other words, many relevant but probably correlated discriminative voxels are missed. Thus, we propose a new variant on stability selection "randomized structural sparsity", which incorporates the idea of structural sparsity. Numerical experiments demonstrate that our method can be superior in controlling for false negatives while also keeping the control of false positives inherited from stability selection.